Abstract: We analyze a model for the activator-repressor oscillator motif proposed as a fundamental oscillating motif in the literature of biological rhythms. We show that incorporating the m-RNA ...

During development, many crucial genes help organisms form properly. One of those genes is myogenic determination gene number 1 (MyoD), which can exert a powerful influence as a “genome organizer." It ...

Tomato fruit ripening is a tightly regulated process involving hormonal signaling, metabolic reprogramming, and epigenetic modulation. Ethylene plays a pivotal role in climacteric fruit ripening, but ...

A high throughput screen of >30,000 diverse repressor domains from across the tree of life identifies repressor domains with unique structures that underpin enhanced epigenetic effector domain potency ...

Required for the transport and metabolism of lactose in Escherichia Coli (E. coli).The lactose operon or lac operon consists of three structural genes namely lacZ, lacY, and lacA that encode proteins ...

The brown planthopper (BPH) is the most destructive pest of rice. The MYB transcription factors are vital for rice immunity, but most are activators. Although MYB22 positively regulates rice ...

Atrial fibrillation (AF) is a highly prevalent condition that can cause or exacerbate heart failure, is an important risk factor for stroke, and is associated with pronounced morbidity and death.

The neuron-restrictive silencer factor (NRSF), also known as repressor element 1 (RE-1) silencing transcription factor (REST) or X2 box repressor (XBR), is a zinc finger transcription factor that is ...

As sessile organisms, plants have to continually adapt their growth and architecture to the ever-changing environment. To do so, plants have evolved distinct molecular mechanisms to sense and respond ...

Researchers have developed two types of programmable repressor elements that can switch off the production of an output protein in synthetic biology circuits by up to 300-fold in response to almost ...