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Programmable CRISPR cuts stem cell timing from months to weeks

On the one hand, more efficient reprogramming could, if poorly controlled, increase the chance of generating cells with unintended self renewal properties. On the other, precise control over gene ...

Asgard Therapeutics appoints Professor Dr Wolfram Brugger as Chief Medical Officer as it advances transformative ‘personalized off-the-shelf’ immunotherapy toward cli…

Medical oncologist (ex AstraZeneca, MorphoSys, Autolus Therapeutics) joins to advance Asgard’s lead asset AT-108 into Phase 1 ...
GEN

Genetic “Dimmer Switch” Offers Precise Gene Expression Control

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...
Scientific American

This method to reverse cellular aging is about to be tested in humans

A burgeoning field is launching its first clinical trial to find out whether dialing back cell development can safely refresh ...
Science Daily

Towards a better understanding of epigenetics and dynamic gene silencing and reactivation

Epigenetics, the dynamic regulation of genetic expression, involves complex molecular mechanisms. While the process of gene silencing by methylating the H3K27 position in histones is understood, not ...
American Association for the Advancement of Science (AAAS)

Prize winner’s research reprograms tumor cells to trigger antitumor immunity

For his work towards developing a novel cancer immunotherapy that turns tumors into their own vaccines, Fábio Rosa has ...
Technology Networks

Fatty Liver Disease Regulated Beyond Gene Expression

Scientists discovered that fatty liver disease alters protein production primarily through translational control rather than ...