Transcription factor IIH, or TFIIH, pronounced "TF two H," is a veritable workhorse among the protein complexes that control human cell activity. It plays critical roles both in transcription—the ...

The avian influenza virus needs to mutate to cross the species barrier and to infect and replicate within mammalian cells. Scientists have now deciphered the structure of the avian influenza virus's ...

Scientists have discovered that a protein once thought to simply help load a factor necessary for the copying of DNA, actually plays a key role in ensuring fast and reliable replication—an insight ...

In the earliest phase of creating human proteins, the protein complex NAC performs an essential task by starting the first ...

DNA replication begins with a set of proteins -- the Origin of Replication Complex (ORC). Researchers published images of the human ORC in exquisite detail, showing how it changes shapes in dramatic ...

“Our lab is generally interested in discovering and characterizing previously unknown or poorly understood factors that are essential for genome maintenance. This is particularly important in the ...

In a recent study published in the journal PLOS One, researchers present the crystal structure of an anti-non-structural protein 9 (nsp) specific nanobody in complex with the severe acute respiratory ...

Mayo Clinic researchers have identified a protein that acts like a traffic controller for DNA, preventing damage during cell division - a discovery that could lead to new cancer therapies, according ...

Researchers found that SMC proteins drive bacterial DNA separation by compacting chromosomes lengthwise, generating repulsive ...